J. Chem. Res. Adv., 02 (01):26-41
sherif Kolkaila : Sherif A. kolkaila
Aim: This study was aimed to synthesis, characterization, spectral, thermal analysis and biological activity studies of montelukast sodium and its metal complexes.
Method and Materials: Chromium, iron, nickel, copper, zinc, cadmium and mercury complexes were proposed to be with octahedral geometry, while manganese and cobalt complexes were with tetrahedral geometry. The thermal properties of the complexes were examined.
Results: The kinetic and thermodynamic parameters were estimated from the TGA and DTA curves. The thermal decomposition of the complexes ended with the formation of metal oxide as a final product except in case of Hg complex. Montelukast sodium complexes show higher biological activity than free ligand for some strains.
Conclusion: It was concluded that synthesis, characterization, spectral, thermal analysis and biological activity of montelukast sodium and its metal complexes were found favorable and effective.