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Original research (Published On: 30-Jun-2021 )

Synthesis, characterization, spectral, thermal analysis and biological activity studies of some montelukast sodium complexes

sherif Kolkaila

J. Chem. Res. Adv., 02 (01):26-41

sherif Kolkaila : Sherif A. kolkaila

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Article History: Received on: 12-Jun-21, Accepted on: 26-Jun-21, Published on: 30-Jun-21

Corresponding Author: sherif Kolkaila

Email: sherifkolkaela@yahoo.com

Citation: Ali AE, Elasala GS, Ibrahim RS and Kolkaila AS (2021). Synthesis, characterization, spectral, thermal analysis and biological activity studies of some montelukast sodium complexes. J. Chem. Res. Adv., 02 (01 ):26-41


Abstract

Aim: This study was aimed to synthesis, characterization, spectral, thermal analysis and biological activity studies of montelukast sodium and its metal complexes.

Method and Materials: Chromium, iron, nickel, copper, zinc, cadmium and mercury complexes were proposed to be with octahedral geometry, while manganese and cobalt complexes were with tetrahedral geometry. The thermal properties of the complexes were examined.

Results: The kinetic and thermodynamic parameters were estimated from the TGA and DTA curves. The thermal decomposition of the complexes ended with the formation of metal oxide as a final product except in case of Hg complex. Montelukast sodium complexes show higher biological activity than free ligand for some strains.

Conclusion: It was concluded that synthesis, characterization, spectral, thermal analysis and biological activity of montelukast sodium and its metal complexes were found favorable and effective.


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