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Original research (Published On: 31-Aug-2023 )

Effect of methanol extract of Cajanus cajan on lipid peroxidation in wistar albino mice

FIDERIKUMO LIVINGSTONE GBEINBO, Varsharani P Karade and Bunmi Kuponiyi

J. Chem. Res. Adv., 04 (02):05-10

FIDERIKUMO LIVINGSTONE GBEINBO : Lead City University, Ibadan, Nigeria

Varsharani P Karade : Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India.

Bunmi Kuponiyi : Lead City University, Ibadan, Nigeria

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Article History: Received on: 25-May-23, Accepted on: 27-Aug-23, Published on: 31-Aug-23

Corresponding Author: FIDERIKUMO LIVINGSTONE GBEINBO

Email: gbeinbolivingstone3@gmail.com

Citation: Gbeinbo LF, Karade VP and Kuponiyi B (2023). Effect of methanol extract of Cajanus cajan on lipid peroxidation in wistar albino mice. J. Chem. Res. Adv., 04 (02 ):05-10


Abstract

Aim: This study was aimed to assess influence of Cajanus cajan's methanol extract (MECC) on lipid peroxidation.

Method and Materials: Eighteen Wistar albino mice (25 to 30g) were divided into three groups. The control group received distilled water, while second and third groups were orally administered 100 mg and 200 mg/kg bwt of MECC respectively, over 14 days. Control group MDA levels were measured at 13.02 ± 2.50 gmol/g. The second group exhibited levels of 3.99 ± 0.00 gmol/g, and the third group measured 4.19 ± 0.12 gmol/g.

Results: Animals treated with MECC displayed significantly reduced MDA levels compared to the control group. Histopathological analysis revealed no significant lesions in the control animals but indicated centrilobular inflammation in the MECC-administered group.

Conclusion: It was concluded that presence of bioactive agents in MECC seeds that contributed to lowered MDA levels in treated animals. Moreover, these bioactive agents appeared to induce centrilobular inflammation in the treated animals.


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