Comparative in-vitro bioequivalence analysis of metformin hydrochloride tablet formulations available in Yenagoa Metropolis, Bayelsa State, Nigeria

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Original research (Published On: 15-May-2023 )

Comparative in-vitro bioequivalence analysis of metformin hydrochloride tablet formulations available in Yenagoa Metropolis, Bayelsa State, Nigeria

SAMUEL, Ebiere Dode and Ikoi Abode Ikenna

J. Chem. Res. Adv., 04 (01):21-26

SAMUEL : Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University

Ebiere Dode : Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island Bayelsa State

Ikoi Abode Ikenna : Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island Bayelsa State

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Article History: Received on: 27-Jan-23, Accepted on: 03-May-23, Published on: 15-May-23

Corresponding Author: SAMUEL

Email: pharmsamuelbunu@gmail.com

Citation: Ebiere D, Samuel JB and Ikoi AI (2023). Comparative in-vitro bioequivalence analysis of metformin hydrochloride tablet formulations available in Yenagoa Metropolis, Bayelsa State, Nigeria. J. Chem. Res. Adv., 04 (01 ):21-26

Abstract

Aim: This study was aimed to use biopharmaceutical analysis and UV/visible spectroscopy to investigate the physicochemical attributes and in-vitro bioequivalence of metformin tablets.

Method and Materials: Glucophage and five other brands of metformin hydrochloride tablets were bought from selected authorized pharmacies in Yenagoa, Bayelsa State, and were all traditional, instantaneous-release oral dose forms. They were coded (M1 - M5), and pharmacopeia assays such as weight uniformity, friability, disintegration, hardness and assay were employed to demonstrate physicochemical equivalency, while percentage purity was determined using UV-spectroscopy.

Results: Based on the UV analysis at 10µg/ml, all brands gave percentage compositions that were within the monograph specifications ranging from 100.21%w/w (M1), 100.23%w/w (M3), 100.34% w/w (M4), 101.26% w/w (M5), and 104.26% w/w (M2), respectively. The metformin content in every brand was optimal from the other physicochemical analysis.

Conclusion: It was concluded that all of the brands of metformin hydrochloride tablets tested founds as per regulatory standards for identification, dissolution, weight uniformity, disintegration, hardness and thickness.

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