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Original research (Published On: 02-Sep-2020 )

Cardiopulmonary effects of dexmedetomidine, midazolam and butorphanol as preanaesthetics to ketamine hydrochloride anaesthesia in dogs

Pradeep Kumar and Rajendra Singh

J. Chem. Res. Adv., 01 (01):10-17

Pradeep Kumar : College of Veterinary and Animal Science (RAJUVAS), Udaipur

Rajendra Singh : College of Veterinary and Animal Science (RAJUVAS), Udaipur

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Article History: Received on: 28-Jul-20, Accepted on: 18-Aug-20, Published on: 02-Sep-20

Corresponding Author: Pradeep Kumar

Email: pkumarvet1@gmail.com

Citation: Singh R and Kumar P (2020). Cardiopulmonary effects of dexmedetomidine, midazolam and butorphanol as preanaesthetics to ketamine hydrochloride anaesthesia in dogs. J. Chem. Res. Adv., 01 (01 ):10-17


Abstract

Aim: The study was carried out to evaluate cardiopulmonary effects of dexmedetomidine, midazolam and butorphanol as preanaesthetics to ketamine hydrochloride anaesthesia in dogs..

Method and Materials: The study was conducted on 32 clinical cases of canine patients divided into four groups, where eight animals were in each group. Dogs were premedicated with dexmedetomidine alone @ 10 µg/kg in DK group, dexmedetomidine @ 10 µg/kg and midazolam @ 0.2 mg/kg in DMK group, dexmedetomidine @10 µg/kg, butorphanol @ 0.2 mg/kg in DBK group and dexmedetomidine @10 µg/kg, midazolam @ 0.2 mg/kg and butorphanol @ 0.2 mg/kg IM in DBMK group. Induction and maintenance of anaesthesia were achieved with ketamine hydrochloride. HR, RR, RT, blood pressure and SpO2 were recorded at 0, P-10, I-5, 10, 20, 30, 40, 50, 60 and 90 minutes.

Results: Significant (P 0.05) alteration in heart rate, respiratory rate and rectal temperature was noticed in all groups after induction of anaesthesia. SBP, DBP and MAP showed the biphasic variation and were significantly changed. SpO2 remained irregular and within physiological limits.

Conclusion: Dexmedetomidine (10µg/kg) with butorphanol 0.2 mg/kg and midazolam 0.2 mg/kg as preanaesthetic with ketamine hydrochloride induces effective surgical anaesthesia in healthy dogs.


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