Himanshu Joshi, Pranav Sharma and Pankaj Yadav
J. Chem. Res. Adv., 02 (02):10-12
Himanshu Joshi : Invertis Institute of Pharmacy, Invertis University, Bareilly, UP, India
Pranav Sharma : Invertis Institute of Pharmacy, Invertis University, Bareilly, UP, India
Pankaj Yadav : Invertis Institute of Pharmacy, Invertis University, Bareilly, UP, India
Coumarins have history of having number of pharmacological activities such as anticoagulant, antithrombotic, antimutagenic, vasodilator, LOX and CLOX inhibitors and it can also used intreatment of edema. The recent success of Coumarins as anti-inflammatory and anticoagulant has further highlighted the importance of this class in medicinal chemistry. Systematic investigation of this class of compound revealed that coumarin derivatives containing pharmacopho reagent plays an important role in medicinal chemistry. This prompted to me, to synthesize new derivatives of Coumarins, 4-Chloro-3-coumarinaldehyde was reacted with halogens substituted aniline and rectified spirit to obtain a new series of 4-chloro-(3-substituted-phenylimino)-methyl-coumarin. A total of 6 compounds were synthesized. Their structures were confirmed by, 1H-NMR and Mass spectroscopy.